Anti-IMPA1 Antibody

The Antibodies.com polyclonal reagent targets IMPA1 (Inositol Monophosphatase 1), a magnesium-dependent phosphatase that hydrolyzes inositol monophosphate into free inositol within the phosphoinositide signaling pathway. Raised in Rabbit and supplied as an unconjugated IgG preparation in a 100 µl volume, this antibody is validated for Western blot (WB) and immunofluorescence (IF) workflows, and it cross-reacts with Human, Mouse, and Rat samples, making it a flexible reagent for comparative studies across model organisms and primary tissue specimens.

IMPA1 is well-expressed in the central nervous system, where lithium-based therapies used in mood disorder research are known to inhibit its enzymatic activity. Researchers studying phosphoinositide pathway turnover, lithium response mechanisms, and neuronal signaling routinely apply this reagent to probe protein expression in brain lysates and fixed neural sections. The polyclonal format increases the likelihood of recognizing multiple epitopes on the target, which is helpful when working with denatured lysates for WB or with fixed cells for IF imaging of subcellular distribution.

Each vial is provided as an unconjugated antibody, leaving end-users free to conjugate it to their preferred reporter dye, fluorophore, or bead-based detection chemistry. Intended for research use, the reagent fits standard immunodetection protocols including western blot analysis of IMPA1 expression in cell lines and tissue homogenates, as well as immunofluorescence staining to visualize localization patterns. Reactivity spans Human, Mouse, and Rat, supporting translational pipelines that move between rodent models and human samples.