Anti-IMPA1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets IMPA1 (Inositol Monophosphatase 1), a magnesium-dependent phosphatase that hydrolyzes inositol monophosphate within the phosphatidylinositol signaling pathway. Supplied as 100 µl of unconjugated antiserum, the reagent has been validated for Western blot (WB) and immunohistochemistry (IHC) applications with confirmed reactivity against human samples.

IMPA1 has attracted sustained interest in neuroscience because it is the presumptive molecular target of lithium salts used to treat bipolar disorder, and polymorphisms in the IMPA1 gene have been examined in genetic association studies of schizophrenia and related affective conditions. The protein is broadly expressed in central nervous system tissue and in several peripheral organs, supporting its use as a marker in studies of phosphoinositide metabolism and receptor-coupled signal transduction.

Typical workflows include probing endogenous IMPA1 in cell and tissue lysates by Western blot, and localizing the protein in formalin-fixed paraffin-embedded sections by IHC. The unconjugated format allows pairing with a wide selection of labeled secondary reagents or direct covalent labeling schemes. For storage, keep the antibody at -20 °C in working aliquots and limit freeze-thaw cycles to preserve antigen-binding activity.