Anti-ILK (Ab-246) Antibody

The Integrin-Linked Kinase (ILK) rabbit polyclonal antibody from Antibodies.com is raised against an epitope mapping to the region surrounding residue 246 of the human ILK sequence, enabling selective detection of this focal adhesion-associated serine/threonine kinase in both native and denatured sample preparations. Supplied as an unconjugated 100 µL liquid aliquot in a single vial, it is validated for Western blot and immunohistochemistry workflows and shows reactivity with human and rat specimens, supporting studies that bridge cell-line models with rodent tissue sections.

ILK localizes to focal adhesion plaques and couples integrin engagement to downstream signaling through the Akt, GSK-3β, and β-catenin axes, influencing cell adhesion, epithelial-mesenchymal transition, anchorage-independent survival, and extracellular-matrix remodeling. Investigators working in cancer invasion, cardiac hypertrophy, and renal fibrotic models use this reagent to monitor endogenous ILK expression and its changes across experimental conditions. The polyclonal format broadens recognition across ILK isoforms and post-translational states, while the unconjugated format lets researchers pair the antibody with custom HRP- or fluorochrome-conjugated secondary reagents of their choice.

For best results, store refrigerated between uses, protect from light, aliquot to limit freeze-thaw cycles, and validate dilutions empirically on the chosen detection platform.