Anti-IL6R Antibody

Rabbit polyclonal reagent raised against the human Interleukin-6 receptor subunit alpha (IL6R, also known as CD126), supplied by Antibodies.com as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. The unconjugated antibody is validated for Western blot and immunohistochemistry workflows, supporting detection of IL6R in human tissue samples and cell lysates.

IL6R is a type I transmembrane glycoprotein that forms the ligand-binding subunit of the IL-6 receptor complex, pairing with the gp130 signal transducer to activate JAK1, TYK2, and downstream STAT3 signaling upon interleukin-6 binding. The receptor exists in a membrane-bound form and a proteolytically shed soluble form (sIL6R), and both are widely investigated as biomarkers and therapeutic targets in inflammatory disease research, including studies of rheumatoid arthritis, Castleman disease, cytokine release syndromes, and tumor microenvironments where IL-6 trans-signaling drives JAK/STAT-dependent proliferation.

The polyclonal format recognizes multiple epitopes across the IL6R extracellular domain, which can be advantageous when probing denatured targets in Western blot and formalin-fixed tissue sections. The host species is Rabbit, the conjugate is unconjugated for secondary antibody flexibility, and reactivity is reported for Human tissue. The 50% glycerol cryoprotectant maintains the reagent as a liquid at subzero storage temperatures for routine bench handling, while 0.1% sodium azide acts as a preservative against microbial contamination over the working shelf life of the vial.