Anti-IL37 Antibody

IL-37 is the only member of the interleukin-1 cytokine family recognized as a natural suppressor of innate inflammation, acting through nuclear translocation and Smad3 signaling to dampen pro-inflammatory mediators such as IL-1β, TNF-α, and IL-6. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against IL-37 and validated for Western blot detection across human, mouse, and rat samples, supporting comparison of inflammatory regulation in cell lysates and tissue homogenates.

Supplied as 100 µl at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.3, the antibody is provided as a liquid aliquot in a vial format. The polyclonal host recognizes multiple epitopes on the target, which improves tolerance to minor species variation and modest degradation products during western blot workflows. Store refrigerated and protected from light; avoid repeated freeze-thaw cycles, which can compromise polyclonal performance. The reagent is intended for research use only and is not suitable for diagnostic procedures.

IL-37 expression is frequently studied in autoimmune disease, tumor microenvironment, and infection models, where its anti-inflammatory role contrasts with the pro-inflammatory actions of other IL-1 family cytokines. Because multiple IL-37 isoforms and processing intermediates exist, pairing this western blot reagent with appropriate loading controls helps researchers interpret expression changes across experimental conditions.