Anti-IL27RA Antibody

This rabbit polyclonal reagent targets the interleukin-27 receptor alpha subunit (IL27RA), a type I cytokine receptor that pairs with gp130 to mediate IL-27 signaling through the JAK/STAT pathway. Distributed by Antibodies.com as a 100 µl vial of unconjugated IgG, the antibody is validated for Western blot and immunofluorescence workflows on human, mouse, and rat samples. The polyclonal format provides recognition of multiple epitopes across the WSX-1/TCCR extracellular domain, which is helpful when probing native receptor conformation in transfected cell lines and primary immune populations such as CD4+ T cells and macrophages. For storage, aliquot the reagent upon receipt and keep frozen at -20°C in working volumes to limit freeze-thaw cycles; avoid repeated freeze-thaw of the stock. The unconjugated format leaves the antibody open to downstream detection choices, including HRP- or fluorophore-conjugated secondary reagents matched to the rabbit host. Researchers studying Th1/Th17 differentiation, inflammatory cytokine signaling, or gp130-family receptor biology commonly pair this antibody with complementary markers such as STAT1 and STAT3 to map IL-27-driven phosphorylation events.