Anti-IL22RA2 Antibody

Rabbit polyclonal antibody targeting IL22RA2 (interleukin-22 receptor subunit alpha 2), the soluble decoy receptor that competitively sequesters IL-22 and dampens downstream JAK/STAT signaling at epithelial and mucosal surfaces. Produced by Antibodies.com, this unconjugated IgG reagent is supplied as 50 µl of rabbit polyclonal antiserum and is validated for immunoblot detection of the human, mouse, and rat protein.

IL22RA2, also called IL-22BP, lacks a transmembrane anchor and acts as a high-affinity natural antagonist of IL-22, contributing to regulation of gut barrier integrity, skin homeostasis, and innate antimicrobial peptide expression. Investigations of inflammatory bowel disease, psoriasis, colorectal inflammation, and epithelial barrier defense commonly use western blot to evaluate IL22RA2 levels across intestinal epithelial cell lines, primary keratinocytes, organoid cultures, and tissue lysates.

The unconjugated format integrates easily with standard chemiluminescent or fluorescent western blot workflows, supporting pairing with an HRP- or fluorophore-conjugated secondary antibody of the user's choice. Cross-reactivity has been confirmed for Human, Mouse, and Rat samples, and the polyclonal IgG preparation recognizes multiple epitopes on the IL22RA2 chain for tolerant detection under varying sample conditions. Aliquot upon receipt to limit freeze-thaw cycles and preserve long-term antibody titer.