Anti-IL21R Antibody

Raised in rabbit against the human Interleukin-21 Receptor, this unconjugated polyclonal reagent from Antibodies.com enables detection of IL21R across human, mouse, and rat samples by Western blot and immunohistochemistry. The reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot, intended for research use only and shipped in a single-use vial that should be stored at -20 °C in aliquots to limit freeze-thaw cycles. IL21R is the ligand-binding subunit of the type I cytokine receptor for IL-21 and is most strongly expressed on B cells, activated CD4+ T cells, NK cells, and lymphoid germinal centres, where the IL-21/IL21R axis drives plasma cell differentiation, Th17 polarisation, and NK cell maturation. Investigators studying autoantibody-mediated disease, chronic inflammatory skin conditions, or immunotherapy targets commonly use anti-IL21R antibodies to map receptor distribution on biopsy material by IHC and to confirm expression in cell lysates by Western blot. The polyclonal format provides recognition of multiple epitopes on the receptor, which is helpful when probing primary cells and tissues where expression levels are low or heterogeneous.