Anti-IL1R2 Antibody

Raised in rabbit against the interleukin-1 receptor type 2 (IL1R2) decoy receptor, this unconjugated polyclonal antibody from Antibodies.com is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3. Validated for Western blot (WB) applications, the reagent is packaged as a 100 µl vial and shows reactivity with both human and mouse IL1R2, enabling cross-species comparative work in a single lot.

IL1R2 is a decoy member of the IL-1 receptor family that lacks a functional TIR signaling domain and instead binds IL-1α, IL-1β, and IL-1 receptor antagonist at the cell surface or as a shed soluble isoform. The target is studied in inflammation research, including the regulation of innate immune responses, and in oncology where altered IL1R2 expression has been linked to tumor microenvironment remodeling. The polyclonal format recognizes multiple epitopes on the receptor, which is helpful when probing for both the membrane-bound and soluble forms of IL1R2 in the same lysate.

For Western blot, dilute the antibody in blocking buffer and titrate against the expression level of IL1R2 in your sample; researchers should validate performance in their specific detection system before drawing quantitative conclusions. The vial should be kept refrigerated and protected from light, with aliquoting recommended to limit repeated freeze-thaw cycles of the working stock.