Anti-IL18RAP Antibody

The IL-18 receptor accessory protein (IL18RAP) reagent is a rabbit polyclonal IgG raised against the accessory subunit of the heterodimeric IL-18 receptor complex. Supplied at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.3, the unconjugated preparation is packaged in a 100 µl vial and intended for use in western blot workflows.

IL18RAP partners with IL-18Rα to confer high-affinity binding of the pro-inflammatory cytokine IL-18 and to drive MyD88-dependent NF-κB and MAPK signaling in Th1 lymphocytes, NK cells, and macrophages. Researchers studying inflammasome-driven cytokine responses, tumor microenvironments, and chronic inflammatory disease models apply this reagent to detect endogenous IL18RAP expression by immunoblotting across human, mouse, and rat samples.

Generated in rabbits and affinity-purified for batch-to-batch consistency, the unconjugated format lets investigators pair it with HRP-, fluorescent-, or biotin-tagged secondary antibodies of their choosing. Aliquot upon receipt and store refrigerated, avoiding repeated freeze-thaw cycles to preserve the preparation for multiple western blot experiments. This Antibodies.com primary antibody has been validated for reactivity against human, mouse, and rat IL18RAP in immunoblotting applications.