Anti-IL18R1 Antibody

Targeting Interleukin-18 Receptor 1 (IL-18Rα, also designated CD218a), this rabbit polyclonal primary antibody from Antibodies.com is supplied as an unconjugated reagent in a 100 µL vial volume. IL-18Rα forms the ligand-binding subunit of the heterodimeric IL-18 receptor complex that mediates pro-inflammatory signaling through NF-κB and MAPK cascades following engagement by its ligand IL-18. The antibody is validated for Western blot and immunohistochemistry, recognizing the endogenous receptor in human, mouse, and rat samples under denaturing SDS-PAGE conditions for WB and in formalin-fixed, paraffin-embedded tissue sections for IHC. Its cross-reactivity profile supports comparative studies of Th1 immune responses, NK cell activation, and inflammatory disease models including autoimmune and infectious contexts. Working aliquots should be prepared on first use to limit repeated freeze-thaw cycles, and the reagent is best stored frozen at -20 °C for long-term stability.