Anti-IL18BP Antibody

The Anti-IL18BP Antibody from Antibodies.com is a rabbit polyclonal IgG reagent raised against human Interleukin-18 Binding Protein, supplied as 50 µl of unconjugated antibody for Western blot workflows. IL18BP functions as a soluble decoy receptor that sequesters mature IL-18, dampening IFN-γ production and downstream Th1 inflammatory signaling. Investigators studying autoimmune pathology, chronic inflammation, or viral immune evasion use this reagent to probe endogenous IL18BP expression in cell lysates and tissue homogenates prepared under reducing conditions. The antibody is validated for immunoblotting of human samples, where it recognizes the native glycoprotein on standard PVDF or nitrocellulose membranes following SDS-PAGE transfer. As an unconjugated primary reagent, it pairs readily with HRP-labeled or fluorophore-conjugated secondary reagents for chemiluminescent or fluorescence detection. The vial format supports flexible experimental design, and storage at 4°C is recommended for short-term use, with aliquoting and freezing at -20°C for longer-term stability to limit freeze-thaw cycles that may erode titer over time.