Anti-IL18BP Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets human interleukin-18 binding protein (IL18BP), a soluble regulator that sequesters the pro-inflammatory cytokine IL-18 and modulates downstream Th1-type immune signaling. Raised in rabbit and supplied as an unconjugated IgG preparation in a 200 µl vial, the reagent is validated for Western blot detection of endogenous IL18BP in human-derived lysates and is offered under the Antibodies.com Primary Antibodies portfolio. IL18BP is actively studied in inflammatory disease, tumor immunology, and host-pathogen interactions, where the balance between free IL-18 and IL-18/IL18BP complexes shapes IFN-γ output and effector cell activation. Researchers applying this antibody to whole-cell lysates resolve IL18BP at a position consistent with its glycosylated mature mass, supporting qualitative comparison of expression across treated versus untreated conditions. The polyclonal format allows recognition of multiple epitopes on the target, which is useful when probing naturally occurring isoforms or partial proteolytic fragments. As an unconjugated reagent, the antibody is compatible with standard secondary systems, including anti-rabbit HRP and fluorescent conjugates, giving flexibility in experimental readout. Intended for research use only, this preparation supports laboratory investigation of IL18BP biology in human cell and tissue models.