Anti-IL18BP Antibody

This monoclonal antibody from Antibodies.com targets IL18BP (Interleukin-18 Binding Protein), a secreted glycoprotein that binds and neutralizes IL-18 cytokine activity, modulating Th1 immune responses and inflammatory signaling. Produced in mouse hosts as an IgG2b isotype, the reagent is supplied as a purified preparation in 100 µl format for Western blot (WB) workflows on human samples. The unconjugated antibody is formulated in 0.1M Tris-Glycine buffer (pH 7.4, 150 mM NaCl) supplemented with 0.2% sodium azide and 50% glycerol for storage stability.

IL18BP research is relevant to studies of autoimmune disease, chronic inflammation, and host defense mechanisms, where dysregulated IL-18 activity contributes to pathology. Researchers apply this clone to detect endogenous IL18BP expression in cell lysates and tissue homogenates by immunoblotting, supporting investigations into innate immunity, caspase-1 inflammasome signaling, and the balance between pro-inflammatory cytokines and their soluble inhibitors.