Anti-IL18 Antibody

Raised in rabbit against human Interleukin-18, this polyclonal antibody from Antibodies.com recognizes IL18, a pro-inflammatory cytokine that promotes interferon-gamma release, NK-cell activation, and Th1 differentiation. Supplied as 100 µl of unconjugated antiserum, the reagent is validated for Western blot and immunohistochemistry workflows and is provided in a single-use vial format.

IL18 sits at the intersection of inflammasome signaling and adaptive immune polarization, so the antibody is widely used to study chronic inflammatory disease, autoimmune models, host-pathogen interactions, and the cytokine landscape of tumor microenvironments. It supports detection of endogenous protein in cultured cell lysates by Western blot and in formalin-fixed paraffin-embedded tissue sections by immunohistochemistry, with the polyclonal antibody format offering broader epitope coverage that can distinguish both the pro-IL18 precursor and its mature, cleaved form.

Working aliquots should be refrigerated and protected from light between uses; the underlying stock is held frozen, and aliquoting upon first thaw is recommended to limit freeze-thaw cycles. Intended for research use only, the reagent suits laboratories investigating cytokine biology, inflammasome activation, and the IL18/IL18BP axis in human disease samples.