Anti-IL17C Antibody

This unconjugated rabbit polyclonal antibody targets human IL17C, a cytokine in the IL-17 family that is distinct from IL-17A and IL-17F and is preferentially expressed by epithelial cells rather than Th17 lymphocytes. From Antibodies.com, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and supports studies of mucosal barrier immunology, keratinocyte signaling, and innate defense pathways in skin and gastrointestinal tissues. Supplied as 100 µl of polyclonal sera from immunized rabbits, the antibody binds the native human IL17C protein and has been applied in research examining epithelial-driven inflammation, including psoriasis models and inflammatory bowel disease investigations where IL17C functions in an autocrine loop to amplify chemokine release. Storage at -20 °C with single-use aliquots preserves binding activity across freeze-thaw cycles, and the unconjugated format lets researchers pair the reagent with their preferred secondary detection system for chromogenic or fluorescent visualization. Human-specific reactivity has been confirmed in the listed applications, and the polyclonal nature of the reagent increases the likelihood of recognition across multiple epitopes of the IL17C target.