Anti-IL17A Antibody

Interleukin-17A (IL17A) is the signature cytokine of Th17 lymphocytes, and this rabbit polyclonal reagent from Antibodies.com provides a specific, unconjugated detection tool for Western blot (WB) and immunofluorescence (IF) studies in human, mouse, and rat samples. Supplied as 100 µl, the antibody supports research into the cytokine's role in mucosal immunity, autoimmunity, and inflammatory disease.

IL17A signals through the IL17RA/IL17RC receptor complex on epithelial, fibroblast, and myeloid cell populations, triggering chemokine, cytokine, and antimicrobial peptide expression that links adaptive T-cell responses to neutrophil recruitment and tissue barrier defense. Investigators working on psoriasis, rheumatoid arthritis synovitis, inflammatory bowel disease, multiple sclerosis, allergic airway inflammation, and tumor-immune contexts routinely apply IL17A-specific antibodies to confirm expression in lesion biopsies, map cytokine-producing cells, and verify genetic or pharmacological interventions in rodent models.

The polyclonal format, raised in rabbit, is well suited for double-labeling experiments in mouse and rat tissue where a secondary antibody of a different host species helps minimize background. Aliquot the vial upon first use, store refrigerated, and limit freeze-thaw cycles to preserve titer across repeated Western blot and immunofluorescence sessions.