Anti-IL16 Antibody [568]

This mouse monoclonal IgG2a antibody targets human interleukin-16 (IL16), a pro-inflammatory cytokine originally characterized as lymphocyte chemoattractant factor (LCF). Produced in mouse and supplied by Antibodies.com as a 100 µg lyophilised preparation, clone 568 is unconjugated and specific for human IL16, validated for ELISA and Western Blot workflows.

IL16 signals through the CD4 receptor and drives recruitment and activation of CD4-positive lymphocytes. Researchers employ anti-IL16 reagents to investigate inflammatory signaling, autoimmune disease mechanisms, and viral immunology, including HIV studies where IL16 modulates viral replication through CD4 engagement. Additional published research contexts include atopic dermatitis, chronic obstructive pulmonary disease, multiple sclerosis, and neuroimmune signaling within the central nervous system, where IL16 expression has been documented in neurons and glial cells.

Common experimental uses include Western Blot detection of the pro-IL16 precursor and its cleaved bioactive C-terminal fragment in cell lysates, alongside ELISA-based quantification of IL16 in cell culture supernatants and tissue extracts. The lyophilised format supports ambient-temperature shipment and convenient reconstitution at working concentration appropriate for the intended assay.