Anti-IL11RA Antibody

This polyclonal reagent from Antibodies.com is raised in rabbit against interleukin-11 receptor subunit alpha (IL11RA), a type I cytokine receptor that mediates IL-11 signaling through the JAK/STAT pathway, notably STAT3 phosphorylation. The unconjugated IgG preparation is supplied as 100 µl of liquid in a single-use vial and is validated for Western blot detection of endogenous IL11RA in human, mouse, and rat samples.

IL11RA functions as the ligand-binding chain of the IL-11 receptor complex, pairing with gp130 to transduce extracellular signals that influence epithelial homeostasis, osteoclast differentiation, and tissue remodeling. Aberrant IL11RA expression has been investigated in gastric, colorectal, and pancreatic carcinomas, as well as in cardiac and pulmonary fibrosis models. Researchers use this antibody to map receptor distribution across normal and diseased tissues, dissect downstream STAT3-dependent transcriptional programs, and characterize IL-11/IL11RA signaling crosstalk with other IL-6 family cytokines.

Provided unconjugated, the reagent is compatible with standard immunoblotting workflows using HRP- or fluorescent-labeled secondary antibodies matched to rabbit IgG. Each lot is quality-controlled for use on whole-cell and tissue lysates prepared with non-denaturing or RIPA-style buffers, and reactivity has been confirmed across the three listed species in published western blot studies.