Anti-IL11 Antibody

Produced in rabbit hosts and validated for Western blot and immunohistochemistry workflows, this unconjugated polyclonal IgG reagent from Antibodies.com targets Interleukin-11 (IL11), a pleiotropic cytokine of the IL-6 family that signals through the IL-11 receptor alpha subunit and the shared gp130 co-receptor. The antibody detects endogenous IL11 in human, mouse, and rat samples, supporting comparative studies of cytokine signaling across species in translational research programs.

IL11 has well-documented roles in hematopoiesis, bone remodeling, epithelial regeneration, and acute-phase inflammatory responses. More recent published work has connected dysregulated IL11 expression to fibroblast activation, organ fibrosis, and tumor-stroma crosstalk in carcinomas, broadening the contexts in which this reagent is applied. In Western blot, the antibody can be used to probe IL11 expression in cell lysates and conditioned media; in IHC, it supports localization studies in formalin-fixed paraffin-embedded tissues to map cytokine-producing cell populations.

The reagent is supplied as 100 µl of antiserum in a standard storage vial. For long-term stability, aliquot the antibody and store frozen at -20°C, avoiding repeated freeze-thaw cycles; for short-term use, refrigerated storage at 4°C is appropriate. This primary antibody is intended for research use only and is not approved for diagnostic or therapeutic applications.