Anti-IL-6Rα Antibody

Raised in rabbits and supplied as an unconjugated polyclonal reagent, this 100 µl aliquot targets the human interleukin-6 receptor alpha subunit (IL-6Rα, CD126), the membrane-bound component that anchors IL-6 signaling at the cell surface and gives rise to soluble IL-6Rα upon proteolytic shedding. Researchers use this primary antibody to dissect classic versus trans-signaling through the JAK/STAT3 pathway, to characterize inflammatory and autoimmune disease models, and to profile tumor microenvironments where IL-6 / IL-6Rα activity drives proliferation and immune cell recruitment.

The reagent is validated for Western blot and ELISA workflows on human samples, supporting cytokine receptor expression studies, biomarker screening, and mechanistic work on IL-6R-blocking biologics such as tocilizumab. For stability, aliquot the antibody upon receipt and store frozen at -20°C to preserve polyclonal reactivity across freeze-thaw cycles; short-term handling on wet ice is suitable for active use. Antibodies.com supplies this anti-IL-6Rα reagent as a 100 µl vial, ready for immediate dilution into blocking, washing, and incubation buffers for downstream immunodetection.