Anti-IL-3Rβ Antibody

From Antibodies.com, this unconjugated rabbit polyclonal reagent targets the alpha subunit of the interleukin-3 receptor (IL-3Rα, also known as CD123) and is supplied as 100 µl at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2. The antibody is validated for Western blot (WB) detection of IL-3Rα in human, mouse, and rat samples, enabling cross-species comparison in a single workflow.

IL-3Rα pairs with the common beta chain (βc, CD131) to assemble the high-affinity heterodimeric IL-3 receptor, triggering JAK2/STAT5, PI3K/AKT, and RAS/MAPK signaling cascades upon IL-3 engagement. Researchers apply this reagent to profile receptor expression on plasmacytoid dendritic cells, basophils, eosinophils, and myeloid progenitors, and to investigate CD123 as both a diagnostic surface marker and a therapeutic target in acute myeloid leukemia (AML), blastic plasmacytoid dendritic cell neoplasm (BPDCN), and related hematological malignancies where overexpression is well documented.

Beyond oncology, the antibody supports mechanistic studies of cytokine-driven proliferation, survival, and differentiation in models of allergic inflammation, asthma, and parasitic infection. The rabbit host and polyclonal format increase the likelihood of recognizing multiple epitopes on IL-3Rα, which is useful when probing denatured lysates, truncated isoforms, or post-translationally modified receptor variants in basic and translational immunology research.