Anti-IL-27Rα Antibody

Polyclonal antibody raised in rabbit against the IL-27 receptor alpha subunit, a type I cytokine receptor also designated WSX-1 or TCCR that pairs with the gp130 signal transducer to form the functional IL-27 receptor complex. From Antibodies.com, the reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, presented as a 100 µl vial format suitable for western blot workflows.

IL-27Rα is expressed on lymphocytes, including naive CD4+ T cells, B cells, and NK cells, and signals predominantly through JAK1, STAT1, and STAT3 to drive Th1 differentiation while restraining pro-inflammatory Th17 responses. Researchers studying cytokine receptor signaling, mucosal immunity, and models of autoimmune or infectious disease use anti-IL-27Rα antibodies to probe receptor expression, downstream phosphorylation events, and the contribution of the IL-27/WSX-1 axis to immune regulation. The antibody is validated for reactivity across human, mouse, and rat samples.

The unconjugated format provides flexibility in secondary antibody choice, and the polyclonal design offers multiple epitope recognition across conserved cytoplasmic and extracellular domains of the receptor. For handling, refrigerate the vial upon receipt in the supplied buffer, aliquot to limit freeze-thaw cycles, and protect from prolonged exposure to ambient temperatures during routine western blot use in cell lysates or tissue homogenates.