Anti-IL-1RII Antibody

Interleukin-1 receptor type II (IL-1RII) is a well-characterized decoy receptor that binds IL-1 cytokines and modulates innate immune signaling without transducing a response, making it a target of interest in inflammation, autoimmune disease, and tissue homeostasis research. This rabbit-derived polyclonal reagent from Antibodies.com was raised against IL-1RII and is supplied at 50 µl per vial in unconjugated form, ready for use in Western blot and ELISA workflows with human samples. The polyclonal format offers recognition of multiple epitopes across the receptor extracellular domain, useful when resolving endogenous expression levels or the truncated soluble IL-1RII isoforms released during inflammatory challenge.

Researchers investigating cytokine receptor regulation, decoy receptor biology, or IL-1 family crosstalk pair this reagent with appropriate secondary antibodies and validated lysate or recombinant protein controls. The product is supplied as a liquid aliquot intended for storage at -20°C in small working volumes to limit freeze-thaw cycles, and the unconjugated format allows flexible choice of HRP, biotin, or fluorophore labelling depending on the chosen assay. Each vial ships with lot-specific quality control data and is intended for research use only in laboratory settings.