Anti-IL-1RI Antibody

Primary antibodies targeting interleukin-1 receptor type I (IL-1RI) from Antibodies.com are affinity-purified polyclonal reagents raised in rabbit. The unconjugated antibody is supplied in a 100 µl vial and is validated for use in Western blot and ELISA workflows against human IL-1RI. IL-1RI is the functional signaling receptor for the pro-inflammatory cytokines IL-1α and IL-1β, transducing ligand binding through MyD88-dependent NF-κB and MAPK cascades and playing a central role in innate immune activation, fever response, and chronic inflammatory disease research. As a polyclonal reagent, this antibody recognizes multiple epitopes across the IL-1RI extracellular domain, supporting detection in cell lysates and membrane preparations from human cell lines and primary tissues. Researchers studying autoimmune, autoinflammatory, and cytokine-driven pathways commonly use this reagent to probe IL-1RI expression levels, receptor trafficking, and downstream signaling events.