Anti-IL-1F8 Antibody

This rabbit polyclonal reagent from Antibodies.com specifically targets human IL-1F8 (also known as IL-36γ), a pro-inflammatory cytokine in the IL-1 family that signals through the IL-36 receptor at epithelial barriers. Supplied as 100 µl of unconjugated polyclonal antisera, the antibody is validated for Western blot and ELISA detection of endogenous IL-1F8 in human samples.

IL-1F8 is produced by keratinocytes and other epithelial cell types, where it activates NF-κB-driven chemokine release associated with cutaneous inflammation and psoriatic lesions. Investigators working on mucosal immunity, skin inflammation, and epithelial innate defense use this reagent to probe cell lysates by WB and to quantify secreted cytokine levels by ELISA. The polyclonal antibody is raised against the native human IL-1F8 sequence, supporting detection of the endogenous protein rather than engineered tagged constructs.

Because the antibody is unconjugated, users can pair it with HRP, biotin, or fluorophore labels of their choice depending on the assay configuration. For routine handling, refrigerate the stock vial upon arrival, aliquot into smaller working volumes, and limit freeze-thaw cycles to preserve polyclonal antibody activity across long-term storage.