Anti-IKKα/β (G182) Antibody

Rabbit polyclonal reagent targeting the G182 epitope shared by IKKα (IKK1) and IKKβ (IKK2), the catalytic serine/threonine kinase subunits of the IκB kinase (IKK) complex that drives canonical NF-κB signaling. These kinases phosphorylate IκBα, flagging the inhibitor for ubiquitination and proteasomal turnover so that NF-κB dimers translocate into the nucleus and induce inflammatory, anti-apoptotic, and innate-immune gene programs.

From Antibodies.com, this unconjugated primary antibody is supplied as 100 µl at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2. It has been validated for immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections and shows reactivity with human, mouse, and rat samples, supporting pathway studies in inflammation, autoimmune disease, and tumor biology research. The polyclonal format broadens epitope coverage across each kinase domain, and the unconjugated format lets researchers pair it with HRP-, biotin-, or fluorophore-conjugated secondary reagents of their choice for chromogenic or fluorescence detection. Store refrigerated between uses; protect from light and limit freeze-thaw cycles to preserve binding activity.