Anti-IKBKE Antibody

The Antibodies.com polyclonal antibody reagent targets the IKBKE kinase, also referred to as IKKε or IKK-i, a non-canonical member of the IKK family that phosphorylates substrates within the NF-κB and IRF signaling cascades. This unconjugated rabbit polyclonal reagent is validated for Western blot and immunohistochemistry workflows against human samples, supplied as 100 µl for research use only.

IKBKE acts downstream of pattern recognition receptors and is induced by inflammatory cytokines and viral nucleic acids, contributing to type I interferon production through IRF3 and IRF7 phosphorylation. The kinase also phosphorylates STAT1 and has emerged as a candidate driver of oncogenic signaling in breast, ovarian, and pancreatic cancers, where elevated IKBKE activity supports tumor proliferation, survival, and metabolic reprogramming.

This primary antibody reagent from Antibodies.com is raised in rabbit and recognizes the human IKBKE protein, enabling researchers to probe endogenous kinase levels in cell lysates and to localize expression in fixed tissue sections. The unconjugated format offers flexibility in secondary antibody choice and detection chemistry, supporting both fluorescence and chromogenic readouts in studies of innate immunity, antiviral sensing, NF-κB pathway activity, and tumor biology.