Anti-IkB-α (phospho-Y42) Antibody

This rabbit polyclonal antibody from Antibodies.com is raised against IκB-α phosphorylated at tyrosine 42 (phospho-Y42), a modification linked to NF-κB signaling in inflammatory and stress response pathways. The reagent is supplied as 100 µl of a 1 mg/ml stock in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and is unconjugated for flexible secondary antibody pairing.

The antibody is specific for the phospho-Y42 epitope on IκB-α, allowing researchers to distinguish tyrosine 42 phosphorylation from the more widely studied serine 32 and serine 36 phosphorylation generated by the canonical IKK pathway. It has been validated for Western blot and immunohistochemistry applications and cross-reacts with Human, Mouse, and Rat samples, supporting comparative work across cultured cells and primary tissue.

Working aliquots can be prepared from the PBS formulation; store refrigerated and protect from light for long term use. For detailed validation images, species-specific signal patterns, and recommended starting dilutions, refer to the Antibodies.com product datasheet.