Anti-Ikaros (C-terminus) Antibody

A primary antibody reagent for transcription factor research, this unconjugated mouse monoclonal from Antibodies.com binds the C-terminus of Ikaros (IKZF1), a zinc-finger protein that orchestrates chromatin remodeling during lymphocyte lineage commitment. Raised against a C-terminal epitope encompassing the dimerization domain, it selectively recognizes the human protein and is supplied as 100 µl of purified immunoglobulin formulated in 0.1 M Tris-Glycine buffer (pH 7.4) with 150 mM NaCl, 0.2% sodium azide, and 50% glycerol. Researchers typically deploy the antibody in western blot and immunoprecipitation workflows to characterize Ikaros expression in lymphoid cell lines, primary hematopoietic progenitors, and leukemia models where IKZF1 deletions drive B-cell acute lymphoblastic leukemia and other hematologic malignancies. The unconjugated format also supports downstream chromatin immunoprecipitation applications and pairing with custom-labeled secondary detection reagents. Because Ikaros dysregulation underlies both acquired leukemias and certain inborn immune deficiencies, the antibody serves translational programs in hematology, immunology, and epigenetics laboratories focused on hematopoietic stem cell fate decisions.