Anti-IGFBP3 Antibody

This unconjugated rabbit polyclonal antibody targets insulin-like growth factor binding protein 3 (IGFBP3), a secreted glycoprotein best known for sequestering circulating IGF-1 and IGF-2 and modulating their bioavailability at peripheral tissues. Supplied by Antibodies.com as a 100 µl vial, the reagent was raised in rabbit and affinity-purified for use in standard laboratory detection workflows.

Validated applications include western blot analysis of cell lysates and immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, enabling studies of growth-factor signaling, apoptosis regulation, and tumor-suppressor activity in both human and mouse models. The antibody recognizes endogenous IGFBP3 and is reactive with human and mouse samples, supporting comparative work across model systems and translational cancer research where altered IGFBP3 expression has been linked to prostate, breast, and hepatocellular carcinoma progression.

As an unconjugated primary reagent, the antibody can be paired with horseradish peroxidase, alkaline phosphatase, or fluorophore-labeled secondary antibodies depending on the chosen detection chemistry, and is intended for research use only.