Anti-IGF2BP3 Antibody

IGF2BP3, an oncofetal RNA-binding protein also known as IMP3, is re-expressed in many human malignancies and has been investigated as a marker of tumor aggressiveness, metastatic behavior, and unfavorable prognosis. The rabbit polyclonal antibody from Antibodies.com targets this protein for use in cancer biology and pathology research workflows.

Supplied as 100 µl of unconjugated antiserum, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human samples. In IHC, IGF2BP3 immunostaining has been used in surgical pathology to help discriminate malignant lesions from benign or reactive counterparts, particularly in pancreatic, cervical, endometrial, renal, and lung specimens. In Western blot, the antibody detects endogenous IGF2BP3 in cell and tissue lysates, supporting studies of mRNA stability, RNA localization, and translational control.

Specifications include polyclonal clonality raised in a rabbit host, reactivity with human IGF2BP3, and an unconjugated format that allows flexible pairing with user-selected secondary antibodies and chromogenic or fluorescent detection chemistries. Researchers focused on cancer stem cell biology, epithelial-mesenchymal transition, and tumor biomarker discovery will find this reagent compatible with standard immunodetection protocols.