Anti-IGF1R (phospho Y1165 + Y1166) Antibody

Phosphorylation of insulin-like growth factor 1 receptor (IGF1R) at the activating tyrosine residues Y1165 and Y1166 marks the ligand-stimulated, catalytically active form of the receptor tyrosine kinase and is widely used in cell signalling studies to track upstream growth-factor responses. This affinity-purified polyclonal reagent from Antibodies.com was raised in rabbit against a phosphorylated peptide encompassing the Y1165 and Y1166 sites of human IGF1R, and is supplied as an unconjugated IgG preparation in a 50 µl vial.

Validated for western blot and immunofluorescence workflows, the antibody highlights activated IGF1R in cell and tissue preparations from human, mouse and rat samples, supporting comparative work across rodent models and primary human material. Detecting the dual-phosphorylated form, rather than total receptor, is particularly useful for studies of receptor activation kinetics, downstream engagement of PI3K/AKT and MAPK cascades, and IGF1R involvement in cancer, metabolic and developmental contexts.

Aliquoting upon receipt and storage at -20 °C preserves phospho-specific binding activity and limits freeze-thaw damage, with a working stock kept cold at 4 °C for active use. The product is intended for research use only and is not cleared for diagnostic or therapeutic applications.