Anti-IGF1R (phospho Y1165 + Y1166) Antibody

The target IGF1R (Insulin-like Growth Factor 1 Receptor) is a transmembrane receptor tyrosine kinase, and phosphorylation at tyrosines 1165 and 1166 within its activation loop is a key marker of receptor activation following IGF-1 ligand engagement. This polyclonal antibody from Antibodies.com selectively detects IGF1R only when dually phosphorylated at these residues, making it suitable for signaling studies in human, mouse, and rat samples. Supplied as 200 µl of unconjugated rabbit IgG, the reagent is validated for Western blot detection of activated receptor bands and immunofluorescence imaging of phosphorylated IGF1R at the plasma membrane. The polyclonal format offers broader recognition across epitopes flanking the phospho-Y1165/Y1166 site compared with a single-clone reagent. Aliquot upon receipt and store frozen at -20 °C, protecting from light and minimizing freeze-thaw cycles to preserve phospho-epitope reactivity. Recommended for in vitro research on the IGF signaling axis, growth factor-driven proliferation, and insulin/IGF cross-talk in cancer and metabolic models.