Anti-IGF1R (phospho Y1131) Antibody

Produced in rabbit as a polyclonal IgG and supplied as 100 µl of unconjugated antiserum, this phospho-specific primary antibody from Antibodies.com targets the insulin-like growth factor 1 receptor at tyrosine 1131, a key autophosphorylation site within the IGF1R kinase activation loop. The Anti-IGF1R (phospho Y1131) Antibody is validated for western blot detection of activated receptor in human cell lysates and tumor tissue samples, supporting studies of ligand-induced signaling, downstream PI3K/AKT pathway activation, and receptor involvement in cancer biology and growth disorder research. Recognition is restricted to the phosphorylated Y1131 epitope with no appreciable cross-reactivity toward non-phosphorylated receptor, allowing clean discrimination of receptor activation dynamics from total expression in time-course and stimulation experiments. Storage at -20°C in single-use aliquots preserves phospho-specific reactivity across repeated freeze-thaw cycles, and standard western blot loading of 10-20 µg of total protein lysate per lane typically yields a clear band corresponding to the receptor beta subunit.