Anti-IGF1R (Ab-1346) Antibody

A rabbit polyclonal antibody from Antibodies.com that recognizes the Insulin-like Growth Factor 1 Receptor (IGF1R) at a region encompassing residue 1346 of the human protein. Supplied as 100 µl of polyclonal rabbit antiserum in an unconjugated format, this primary reagent is validated for Western blot and immunohistochemistry applications on human samples.

IGF1R is a transmembrane receptor tyrosine kinase that transduces IGF-1 and IGF-2 binding into downstream PI3K/AKT and RAS/MAPK signaling, governing proliferation, survival, and metabolic responses. The receptor has been widely studied in cancer cell growth, therapy-resistance mechanisms, insulin-sensitivity models, and developmental biology. Researchers apply this antibody to monitor total receptor levels, characterize downstream pathway engagement, and localize receptor expression in fixed tissue sections.

For best stability, store the vial at -20 °C in working aliquots to limit freeze-thaw cycles, and protect from light while thawed. The product is intended for research use only and is suited to cell lysate immunoblotting as well as formalin-fixed, paraffin-embedded tissue staining workflows in academic and translational laboratory settings.