Anti-IGF-IR Antibody

This rabbit polyclonal reagent from Antibodies.com targets the insulin-like growth factor 1 receptor (IGF-IR), a transmembrane tyrosine kinase implicated in normal growth signaling and in the dysregulated proliferation observed across multiple tumor types. Supplied as 100 µl of unconjugated antisera, the antibody is validated for western blot detection of IGF-IR in lysates from human, mouse, and rat samples, with reactivity also demonstrated in immunohistochemical staining of formalin-fixed tissue sections. Researchers studying receptor phosphorylation, downstream PI3K/Akt and MAPK pathway activity, and IGF axis involvement in breast, prostate, and pediatric tumor models routinely use this reagent to evaluate expression levels, ligand-induced activation, and receptor downregulation following pharmacological inhibition. As a polyclonal preparation, the antibody recognizes multiple epitopes across the receptor, supporting consistent signal in western blot and immunohistochemistry workflows. Each vial is intended for research use only and supports laboratory applications in cell signaling, cancer biology, and metabolic disease research.