Anti-IGF-1R (phospho-Y980) Antibody

The phospho-Y980 site on the type 1 insulin-like growth factor receptor (IGF-1R) marks the activated kinase domain, and this rabbit polyclonal reagent from Antibodies.com is raised specifically against that phosphorylated epitope. Provided as an unconjugated IgG preparation at 1 mg/ml in phosphate buffered saline (pH 7.2) with 0.05% sodium azide as a preservative, it is supplied as a 100 µl vial sized for routine immunohistochemistry workflows. Reactivity has been validated against human, mouse, and rat tissue sections, supporting cross-species studies of receptor activation in tumor biology, insulin signalling, and developmental research.

Phosphorylation at Y980 lies within the activation loop of the IGF-1R kinase domain and is one of the earliest autophosphorylation events following ligand binding, making this antibody a useful marker for tracking receptor activation status rather than total receptor expression. It performs well on formalin-fixed paraffin-embedded sections, allowing researchers to localize activated receptor signalling within specific tissue compartments and cell types. Standard IHC protocols using peroxidase or fluorescence-based detection systems are compatible, and the polyclonal format offers tolerance for minor variations in the surrounding epitope context, which can be helpful when comparing activated receptor distribution across different tissue samples.