Anti-IGF-1R (Ab-1280) Antibody

Antibodies.com offers this rabbit polyclonal antibody raised against the Insulin-like Growth Factor 1 Receptor (IGF-1R), with the Ab-1280 designation indicating recognition of an epitope positioned around residue 1280 in the receptor's intracellular kinase domain. IGF-1R is a transmembrane receptor tyrosine kinase that transduces signals from IGF-1 and IGF-2 ligands through the PI3K/AKT and RAS/MAPK pathways, governing cell proliferation, survival, and metabolic responses in many tissue types. The unconjugated reagent is supplied as 100 µl in a vial and is validated for western blot and immunohistochemistry workflows using human and mouse specimens. Investigators working on cancer cell signaling, insulin resistance, or developmental growth pathways commonly employ this reagent to probe receptor expression and activation status in lysates and tissue sections. The polyclonal antibody format allows binding across multiple epitopes on the target, supporting robust detection across both standard expression-level and phospho-context applications. Store refrigerated upon arrival; aliquot to working volumes to limit freeze-thaw cycles and preserve functional activity over the lifetime of the reagent.