Anti-IGF-1R (Ab-1161) Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody targets Insulin-like Growth Factor 1 Receptor (IGF-1R), with the immunogen corresponding to a region around residue 1161 of the human receptor. Distributed by Antibodies.com as 100 µL of liquid, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows, giving laboratories flexibility across cell-lysate, fixed-section, and cultured-cell applications.

The reagent detects endogenous IGF-1R in human, mouse, and rat samples, supporting comparative studies of receptor tyrosine kinase signaling in cancer biology, metabolic disease, and developmental research. IGF-1R drives the PI3K/AKT and RAS/MAPK cascades downstream of IGF-1 and IGF-2 ligands, so the antibody is commonly used to characterize receptor expression, activation, and subcellular localization in tumor cell lines and tissue sections relevant to breast cancer, hepatocellular carcinoma, and insulin-resistance models.

As an unconjugated preparation, the antibody can be paired with HRP, biotin, or fluorophore secondary reagents of the user's choosing, or used directly in indirect staining protocols. Store the vial at -20 °C in single-use aliquots to limit freeze-thaw cycles and preserve antibody titer. Each preparation is supplied as a 100 µL vial, intended for research use only.