Anti-IFT88 Antibody

Raised in rabbit, this unconjugated polyclonal IgG antibody recognizes IFT88, a central component of the intraflagellar transport B (IFT-B) complex that drives protein trafficking along axonemal microtubules and is required for the assembly and maintenance of primary and motile cilia. IFT88, also known as Polaris or TTC10, is widely studied in the context of Hedgehog signal transduction, left-right axis determination, and ciliopathies such as autosomal recessive polycystic kidney disease and Bardet-Biedl syndrome.

The 100 µl liquid aliquot from Antibodies.com is validated for Western blot detection of endogenous IFT88, immunohistochemistry on fixed tissue sections to localize ciliary structures, and immunofluorescence imaging of centrosomes and basal bodies in cultured cells. Cross-reactivity has been confirmed against human and mouse orthologues, making the reagent appropriate for comparative studies in mammalian cell lines, primary cultures, and mouse tissue models of ciliary dysfunction, where loss or mislocalization of IFT88 is commonly used as a phenotypic readout of cilium integrity.