Anti-IFN-γRα (phospho-Y457) Antibody

The phospho-Y457 site on the interferon-gamma receptor alpha chain (IFN-γRα) is a well-characterized tyrosine residue whose phosphorylation is required for downstream JAK-STAT signaling following interferon-gamma engagement.

This rabbit polyclonal reagent from Antibodies.com specifically recognizes IFN-γRα only when phosphorylated at tyrosine 457, enabling selective detection of the activated receptor form in cell lysates.

Supplied at 1 mg/ml in phosphate buffered saline (pH ~7.2) with 0.05% sodium azide as a preservative, the antibody is unconjugated and validated for Western blot analysis across human, mouse, and rat samples. Each vial contains 100 µl of polyclonal antiserum, sufficient for multiple immunoblotting experiments.

The reagent is intended for research use only, supporting studies of cytokine receptor signaling, macrophage activation, Th1 immune responses, and interferon-driven gene regulation. Researchers probing STAT1 recruitment, JAK1/JAK2 kinase activity, or receptor internalization dynamics will find this phospho-specific antibody useful for distinguishing baseline receptor pools from signal-competent, phosphorylated populations.

Storage recommendation: keep refrigerated at 4°C; avoid repeated freeze-thaw cycles to preserve phospho-epitope recognition. The sodium azide component permits short-term handling at room temperature for routine western blot workflows.