Anti-IFM3 Antibody

Raised in rabbit, this unconjugated polyclonal reagent from Antibodies.com targets the interferon-induced transmembrane protein IFITM3, a small membrane-associated effector of innate antiviral immunity. IFITM3 accumulates on endosomal and lysosomal compartments, where it restricts the cytoplasmic entry of diverse enveloped viruses including influenza A, dengue, Zika, and SARS-CoV-2, making it a focus of studies into host-pathogen interactions, viral tropism, and the cellular basis of immune defense. Validated for Western blot (WB) and immunofluorescence (IF), the antibody detects the endogenous human protein, supporting work in cell lines and primary cultures where researchers examine induction by type I and type II interferons, subcellular trafficking during infection, and the impact of common IFITM3 variants such as rs12252 on disease susceptibility. The reagent is supplied as 100 µL of unconjugated antiserum, suitable for fluorescent or chromogenic secondary labeling in immunofluorescence imaging and membrane-fraction Western blot workflows, and is intended for research use only in academic and translational laboratories investigating mucosal and systemic antiviral responses.