Anti-IFIH1 Antibody

This rabbit polyclonal reagent from Antibodies.com targets IFIH1, the interferon-induced helicase 1 protein also known as MDA5, a cytoplasmic pattern recognition receptor of the RIG-I-like receptor family that senses viral double-stranded RNA and drives type I interferon signaling. Supplied unconjugated at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.3, the antibody is provided in a 100 µl vial suitable for Western blot workflows. The polyclonal format enables multi-epitope recognition of IFIH1 in human, rat, and mouse samples, supporting studies of innate antiviral immunity, interferon-driven responses, and the contribution of MDA5 to autoinflammatory and autoimmune disease mechanisms. Because endogenous IFIH1 expression is interferon-inducible and tissue-dependent, appropriate positive and negative controls should be included in each blot to confirm signal specificity. The sodium azide preservative supports refrigerated storage for routine use, while long-term stability is generally maintained by freezing aliquots to limit freeze-thaw cycles of the stock solution.