Anti-IFI16 Antibody

This polyclonal antibody from Antibodies.com targets IFI16, a nuclear interferon-inducible protein that acts as a cytosolic and nuclear DNA sensor within the PYHIN protein family. IFI16 detects double-stranded DNA and activates STING-dependent type I interferon signaling, and it also participates in AIM2-like inflammasome assembly. The reagent is supplied as 100 µl of unconjugated antiserum raised in rabbit, suitable for western blot, immunohistochemistry, and immunofluorescence workflows on human samples. Researchers studying innate immune DNA sensing, inflammasome biology, and autoantibody biomarkers in conditions such as systemic lupus erythematosus and Sjögren's syndrome use anti-IFI16 antibodies to track endogenous protein expression and subcellular localization. The unconjugated format allows flexible pairing with fluorophore- or enzyme-conjugated secondary reagents in custom detection protocols.