Anti-ICOS Antibody

Supplied through Antibodies.com, this research-grade reagent is a rabbit polyclonal preparation raised against the inducible T-cell co-stimulator (ICOS) protein, produced by immunizing rabbits with recombinant human ICOS and affinity-purified against the immunogen. The unconjugated antibody is provided as a 50 µL aliquot at 1.0 mg/mL in a phosphate-buffered saline formulation (pH 7.4) containing 150 mM NaCl, 0.02% sodium azide, and 50% glycerol, with no magnesium or calcium salts, and it should be stored at –20 °C with freeze/thaw cycles avoided to preserve activity. According to the supplier datasheet, the antibody specifically detects the endogenous level of total ICOS and is validated for Western blotting (WB) and immunocytochemistry/immunofluorescence (ICC/IF) applications. Reactivity has been confirmed in human, mouse, and rat samples, making it suitable for cross-species studies of T-cell costimulatory signalling in immunology and oncology research. The host species is rabbit and the clonality is polyclonal, so the reagent will recognise multiple epitopes across the ICOS target — a useful property for detecting low-abundance antigens or for use in assays where epitope masking may otherwise be a concern. Researchers should treat the product as for research use only and not for diagnostic or therapeutic applications. For laboratories working on checkpoint molecules, follicular helper T-cell biology, or autoimmune disease models, this Antibodies.com polyclonal offers a flexible, unconjugated format that can be readily paired with secondary detection reagents of the user's choice, while the buffered, azide-containing glycerol formulation is compatible with long-term storage and repeated experimental use.