Anti-ICOS Antibody

The Antibodies.com rabbit polyclonal antibody targets ICOS (Inducible T-cell COStimulator), also designated CD278, a member of the CD28/CTLA-4 immunoglobulin receptor superfamily upregulated on activated CD4+ and CD8+ T lymphocytes and constitutively expressed on follicular helper T cells.

Produced in rabbit as an unconjugated polyclonal reagent, this antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows and cross-reacts with ICOS from human, mouse, and rat samples, supporting comparative studies across common immunological model systems.

ICOS engagement by its ligand ICOSL (B7-H2/CD275) delivers the PI3K-mediated costimulatory signal required for IL-4 and IL-21 production, germinal center formation, and immunoglobulin class switching, which is why this reagent is widely used in research programs investigating autoimmunity, transplant tolerance, and checkpoint-based cancer immunotherapy.

The 100 µl format is supplied as a liquid aliquot; refrigerate on arrival, avoid repeated freeze-thaw cycles, and protect from light to preserve binding activity across multiple staining and blotting experiments.