Anti-HYAL3 Antibody

The Anti-HYAL3 Antibody from Antibodies.com is a rabbit polyclonal reagent raised against human hyaluronidase 3, a lysosomal enzyme that contributes to the turnover of hyaluronic acid and other glycosaminoglycans. Supplied as 100 µl of unconjugated antiserum, the antibody is validated for Western blot and immunohistochemistry workflows on human samples, supporting detection of endogenous HYAL3 protein in cell lysates and fixed tissue sections.

HYAL3 belongs to a family of acid-active hyaluronidases in the human genome (alongside HYAL1, HYAL2, HYAL4, and SPAM1/PH-20) and resides predominantly in lysosomes, where it functions at acidic pH to cleave hyaluronic acid into shorter oligosaccharides. Although less extensively characterized than HYAL1 or HYAL2, it has appeared in studies of tumor biology, glycosaminoglycan catabolism, and lysosomal storage research.

As a polyclonal reagent, the antibody recognizes multiple epitopes on HYAL3, which can be helpful when working with truncated isoforms or partially denatured samples. The unconjugated format leaves the chemistry open: researchers can conjugate the antibody to horseradish peroxidase, biotin, fluorophores, or other labels according to their experimental design. Provided in a 100 µl volume, this reagent is intended for research use only and offers a flexible option for laboratories probing hyaluronidase expression and function in human cells and tissues.