Anti-HYAL1 Antibody

This rabbit-derived polyclonal reagent from Antibodies.com targets HYAL1, the lysosomal hyaluronidase responsible for degrading high-molecular-weight hyaluronic acid into smaller fragments. Validated for Western blot (WB) and immunohistochemistry (IHC) on human samples, the antibody is supplied as a 100 µl aliquot at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, allowing convenient storage at -20 °C and protection from repeated freeze-thaw cycles.

HYAL1 is a key regulator of extracellular matrix turnover and has been extensively investigated in tumour biology, where altered hyaluronan catabolism is associated with bladder, prostate and breast carcinoma progression, as well as in studies of inflammation and tissue remodelling. Researchers use this unconjugated primary antibody to probe HYAL1 expression in cell lysates, tissue sections and relevant disease models, supporting workflows ranging from signal-pathway characterisation to biomarker discovery. The polyclonal format provides broader epitope coverage than monoclonal alternatives, making it a practical choice for detecting endogenous HYAL1 across varied human sample preparations.