Anti-HUS1B Antibody

Raised in rabbit as an affinity-purified polyclonal IgG reagent from Antibodies.com, this antibody is supplied as a 100 µl liquid aliquot and validated for Western blot detection of the HUS1 checkpoint clamp component B paralog in human, mouse, and rat sample backgrounds.

HUS1B assembles into alternative 9-1-1-like checkpoint clamps with RAD9B and RAD1, and the reagent is used to monitor paralog levels in whole-cell lysates and tissue homogenates following genotoxic insults such as hydroxyurea, ionizing radiation, or UV exposure. With a predicted molecular weight near 36 kDa, HUS1B is implicated in ATR-Chk1 signaling and replication fork integrity, and the antibody supports work on the composition of non-canonical RAD9B-containing clamp assemblies in mammalian cells.

For continuous use, store at -20°C and avoid repeated freeze-thaw cycles; the lot-specific data sheet shipped with each vial from Antibodies.com should be consulted for recommended working dilutions and handling details.